Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana

Generation of an anti-tumour immune resp

Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression

✍ Richard G. Vile; Simon Castleden; John Marshall; Richard Camplejohn; Carol Upton 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 471 KB

Direct delivery of the herpes simplex virus thymidine kinase (HSVtk) gene, in combination with the prodrug ganciclovir (GC), has been used for the treatment of localised, inoperable tumours. Several groups have shown that when rodent tumours are ablated in vivo with suicide genes, anti-tumour immuni