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Expression of an HLA-Bw6-related specificity by the HLA-Cw3 molecule

✍ Scribed by Corine Layet; Terry Delovitch; Pierre Ferrier; Danielle H. Caillol; Bertrand R. Jordan; François A. Lemonnier

Publisher: Springer-Verlag
Year: 1985
Tongue: English
Weight: 670 KB
Volume: 21
Category: Article
ISSN: 0093-7711
DOI: 10.1007/bf00430930

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✦ Synopsis

Radioimmunoassay of HLA-transformed mouse L cells expressing A3, A24, B7, or Cw3 HLA class I molecules with a set of monomorphic monoclonal antibodies distinguishes between A3-A24 and B7-Cw3 patterns of reactivity. Analyses with Bw6-specific monoclonal antibodies and a human alloantiserum demonstrate the expression by the HLA-Cw3 molecules of a Bw6 public specificity related to but not identical with that expressed by the HLA-B7 molecules. Exon-shuffling experiments and inhibition studies of monoclonal antibody cell-surface fixation indicate that similar parts of B7 and Cw3 molecules account for their serological cross-reactivity.

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