Expression of alternative forms of differentiation inhibiting activity (DIA/LIF) during murine embryogenesis and in neonatal and adult tissues

Protein kinase Cα is differentially acti

Protein kinase Cα is differentially activated during neonatal and adult erythropoiesis and favors expression of a reporter gene under the control of the Aγ globin-promoter in cellular models of hemoglobin switching

✍ Angela Di Baldassarre; Mariacristina Di Rico; Antonella Di Noia; Tiziana Bonfini 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 369 KB

## Abstract PKCα was found to be expressed (mRNA and protein) throughout the in vitro maturation of primary human erythroblasts but its activity (phosphorylation levels and nuclear localization) was consistently higher in cells derived from human neonatal rather than adult blood. Since the γ/γ + β