Expression of adenylyl cyclase isoforms in neutrophils
โ Scribed by Ling-Chu Chang; Chung-Jieh Wang; Yi-Lee Lin; Jih-Pyang Wang
- Book ID
- 114150316
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 192 KB
- Volume
- 1640
- Category
- Article
- ISSN
- 0167-4889
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Cyclic adenosine monophosphate (cAMP) is generated by adenylyl cyclases (ACs), a group of enzymes with different tissue specificity and regulation. We hypothesized that AC isoforms are heterogeneously expressed along the biliary tree, are associated with specific secretory stimuli, and are different
We examined the effect of n-alkanols on adenylyl cyclase isoforms (types II and V) overexpressed in insect cells. Ethanol stimulated the type II isoform but not the type V isoform. Ethanol stimulated type II adenylyl cyclase greater than GTPgS, and the treatment of the membrane with GDPbS or cholera