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Expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic cartilage

✍ Scribed by Satoko Naito; Takayuki Shiomi; Aiko Okada; Tokuhiro Kimura; Miyuki Chijiiwa; Yoshinari Fujita; Taku Yatabe; Koichiro Komiya; Hiroyuki Enomoto; Kyosuke Fujikawa; Yasunori Okada

Book ID: 115175860
Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 334 KB
Volume: 57
Category: Article
ISSN: 1320-5463
DOI: 10.1111/j.1440-1827.2007.02167.x

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## Abstract ## Objective To determine whether aggrecanase (ADAMTS) activities in articular cartilage can directly lead to the release of hyaluronan (HA) and hyaladherins (aggrecan G1 domain and link proteins), as may occur ex vivo during stimulation of cartilage explants with interleukin‐1 (IL‐1)