Expression of acid cysteine proteinase inhibitor (acpi) in the normal human prostate, benign prostatic hyperplasia and adenocarcinoma
✍ Scribed by Karl-Ove Söderström; Matti Laato; Ping Wu; Väinä K. Hopsu-Havu; Martti Nurmi; Ari Rinne
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- French
- Weight
- 515 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Acid cysteine proteinase inhibitor (ACPI or cystatin A) is a protein (I 2 kDa) which inhibits the action of several cysteine proteinases, e.g. cathepsins B, H, L and S. In this study the cellular location of ACPl has been immunohistochemically investigated in the normal human prostate, in benign prostatic hyperplasia (BPH) and in adenocarcinoma. ACPl was found in the basal epithelial cells of the normal prostate. The secretory epithelial cells did not express ACPI. In the hyperplastic prostate, the expression of ACPl was decreased and it was also expressed more focally in the basal cells. Hyperplastic basal cells also expressed ACPI. In prostatic adenocarcinoma, no ACPl expression was found. The absence of ACPl expression was obvious and if the sections contained both benign and malignant cells, only the benign glandular structures always expressed ACPI. The results suggest that expression of ACPl might be related to prostatic epithelial cell proliferation and differentiation. Possibly the detection of ACPl in tissue sections might be helpful in identifying prostatic adenocarcinoma, especially in cases with small carcinomatous foci.