Expression of ABH and lewis blood group antigens in combined hepatocellular-cholangiocarcinoma. Possible evidence for the hepatocellular origin of combined hepatocellular-cholangiocarcinoma
✍ Scribed by Yoshio Okada; Kenji Jinno; Shousuke Moriwaki; Shigeru Morichika; Shou-Ichiro Torigoe; Terukatsu Arima; Hideo Nagashima; Hilary Koprowski
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 946 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
Expression of ABH, Lewis, and sialyl Lea antigens was studied in five combined hepatocellular-cholangiocarcinomas. Formalin-fixed liver tissues were immunostained for those antigens using well-characterized monoclonal antibodies and an avidin-biotin-peroxidase complex (ABC) method. Results were compared with those obtained in normal liver tissues and cholangiocarcinomas, and also with the previous observations of the authors on hepatocellular carcinomas. Although not detected in normal parenchymal liver cells, A, H, Lewis, and sialyl Lea antigens were found in combined hepatocellularcholangiocarcinoma cells. Incompatible A antigen also was detected in one blood type 0 patient. Distribution and intensity of the antigens were similar to those in hepatocellular carcinomas and different from those in cholangiocarcinomas. No preferential accumulation of blood-group antigens could be found in the area of cholangiocarcinoma-like differentiation of the combined hepatocellularcholangiocarcinoma. The observations suggested that 1. Regional morphological differentiation of the hepatocellular-cholangiocarcinoma might not be always associated with the change in the expression of the blood group antigens. Moreover, the expression was essentially the same between the hepatocellular-cholangiocarcinoma and the typical hepatocellular carcinoma.
- The hepatocellular-cholangiocarcinoma, therefore could be a variant of the hepatocellular carcinoma.
Cancer 60345-352.1987.
ARENCHYMAL LIVER CELLS and biliary epithelial P cells are developed from a common liver primordium. ' At the relatively early stage of embryogenesis, the hepatic cord differentiates into the parenchymal liver cells, from which the intrahepatic biliary epithelial cells are derived.' Although they have the same cellular ori- gin, the two cell types have completely different phenotypes, such as the cellular morphology and the structural components, and they constitute the different tissues. Cancers (hepatocellular carcinoma [HCCa] and cholan-From the