Expression of a potential metastasis suppressor gene (nm23) in thyroid neoplasms
β Scribed by David R. Farley; Norman L. Eberhardt; Clive S. Grant; Daniel J. Schaid; Jonathan A. van Heerden; Ian D. Hay; Sundeep Khosla
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 732 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0364-2313
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## Abstract __p53__, a tumor suppressor gene involved in the G1 cell cycle checkpoint, is also the most frequently mutated gene in human cancer. In addition, p53 modifies the ability of tumor cells to metastasize. The metastasisβassociated gene __Nm23βH1__, which encodes an 18βkDa nucleoside diphos
Metastases of various malignancies have been shown to be inversely related to the abundance of nm23 protein expression. However, the downstream pathways involved in nm23-mediated suppression of metastasis have not been elucidated. In the present investigation, we used cDNA microarrays to identify no