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Expression of a dominant negative estrogen receptor alpha variant in transgenic mice accelerates uterine cancer induced by the potent estrogen diethylstilbestrol

✍ Scribed by Vicki L. Davis; Retha R. Newbold; John F. Couse; Sheri L. Rea; Katie M. Gallagher; Katherine J. Hamilton; Eugenia H. Goulding; Wendy Jefferson; E.M. Eddy; Bill C. Bullock; Kenneth S. Korach

Book ID: 118500773
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 580 KB
Volume: 34
Category: Article
ISSN: 0890-6238
DOI: 10.1016/j.reprotox.2012.08.005

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The role of estrogen and the estrogen receptor (ER) in the induction and promotion of tumors was investigated by using transgenic MT-mER mice, which overexpress the ER. It was hypothesized that because of this abnormal expression of the ER, the reproductive-tract tissues of the MT-mER mice may be mo