Expression of 17β-hydroxysteroid dehydrogenases and other estrogen-metabolizing enzymes in different cancer cell lines
✍ Scribed by T. Šmuc; T. Lanišnik Rižner
- Book ID
- 113517829
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 513 KB
- Volume
- 178
- Category
- Article
- ISSN
- 0009-2797
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## Abstract Steroid regulation of 17β‐hydroxysteroid dehydrogenase (17‐HSD) was studied in the T‐47D human breast‐cancer cell line, using a radioimmunoassay. In addition, 3 mRNA species (2.4, 1.4, and 0.9 kb) specific for the enzyme were shown to be present in these cells. All the synthetic progest
I7f3-hydroxysteroid dehydrogenase (I 7HSD) type I converts the weakly active estrogen, estrone, into highly active estradiol. In addition to being essential for gonadal estradiol biosynthesis, the enzyme is also expressed in a significant proportion of breast tumors. In order to study the role of th