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Expression of 11beta-hydroxysteroid dehydrogenase 2 contributes to glucocorticoid resistance in lymphoblastic leukemia cells

✍ Scribed by Shuji Sai; Yuichi Nakagawa; Rie Yamaguchi; Masako Suzuki; Kimiyoshi Sakaguchi; Shuichi Okada; Jonathan R. Seckl; Takehiko Ohzeki; Karen E. Chapman


Book ID
113773505
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
339 KB
Volume
35
Category
Article
ISSN
0145-2126

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Differential regulation of 11Ξ²-hydroxyst
✍ Shuji Sai; Yuichi Nakagawa; Kimiyoshi Sakaguchi; Shuichi Okada; Hiroyoshi Takaha πŸ“‚ Article πŸ“… 2009 πŸ› Elsevier Science 🌐 English βš– 251 KB

Glucocorticoid therapy forms a crucial first-line treatment for childhood acute lymphoblastic leukemia (ALL). However, glucocorticoid resistance is a therapeutic problem with an unclear molecular mechanism. 11beta-Hydroxysteroid dehydrogenase-1 (11beta-HSD1) is expressed in glucocorticoid target tis