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Expression and structural properties of a chimeric protein based on the ectodomains of E1 and E2 hepatitis C virus envelope glycoproteins

✍ Scribed by Daniel Tello; Mar Rodríguez-Rodríguez; Belén Yélamos; Julián Gómez-Gutiérrez; Sara Ortega; Beatriz Pacheco; Darrell L. Peterson; Francisco Gavilanes


Book ID
116829126
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
476 KB
Volume
71
Category
Article
ISSN
1046-5928

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The hepatitis C virus (HCV) envelope glycoprotein E1 has been widely employed as a potential vaccine antigen in clinical research. A truncated form (amino acids 192-326) of the E1 protein (E1y) was expressed in the yeast Hansenula polymorpha and purified from the cell lysate. E1y forms protein parti