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Expression and somatic mutations ofSDHAF2 (SDH5), a novel endocrine tumor suppressor gene in parathyroid tumors of primary hyperparathyroidism

✍ Scribed by Lee F. Starker; Alberto Delgado-Verdugo; Robert Udelsman; Peyman Björklund; Tobias Carling


Book ID
107571491
Publisher
Springer
Year
2010
Tongue
English
Weight
296 KB
Volume
38
Category
Article
ISSN
0969-711X

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Somatic mutations of the PTEN tumor supp
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The PTEN (MMAC1/TEP1) tumor suppressor gene was recently isolated and mapped to human chromosome band 10q23. Homozygous deletions and mutations of PTEN were observed in cell lines and sporadic cancers of the breast, kidney, and central nervous system. Germline mutations in PTEN were recently found i