𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Expression and regulation of pOb24 and lipoprotein lipase genes during adipose conversion

✍ Scribed by C. Dani; E.-Z. Amri; B. Bertrand; S. Enerback; G. Bjursell; P. Grimaldi; G. Ailhaud

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
703 KB
Volume
43
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

Lipoprotein lipase (LPL) and pOb24 mRNAs are known to be early markers of adipose cell differentiation. Comparative studies of the expression of pOb24 and LPL genes during adipose conversion of Ob 177 1 preadipocyte cells and in mouse adipose tissue have shown the following: 1) the expression of both genes takes place at confluence; this event can also be triggered by growth arrest of exponentially growing cells at the G,/S stage of the cell cycle; 2) In contrast to glycerol-3-phosphate dehydrogenase mRNA, the emergence of pOb24 and lipoprotein lipase mRNAs requires neither growth hormone or tri-iodothyronine as obligatory hormones nor insulin as a modulating hormone; 3) in mouse adipose tissue, pOb24 mRNA is present at a high level in stromal-vascular cells and at a low level in mature adipocytes, and in contrast LPL mRNAs are preferentially expressed in mature adipocytes. Thus, these two genes do not appear to be regulated in a similar manner, as also shown by the differential inhibition of their expression by tumor necrosis factor (TNF) and transforming growth factor6 (TGF-P).

πŸ“œ SIMILAR VOLUMES

Expression and regulation of golli produ
Expression and regulation of golli products of myelin basic protein gene during in vitro development of oligodendrocytes
✍ Maria I. Givogri; Ernesto R. Bongarzone; V. Schonmann; Anthony T. Campagnoni πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 842 KB

## Abstract The myelin basic protein (MBP) gene produces two families of proteins, the classic MBPs, important for myelination of the CNS, and the golli proteins, whose biological role in oligodendrocytes (OLs) is still unknown. The goals of this work were to study the in vitro pattern of expressio

Coordinate up-regulation of low-density
Coordinate up-regulation of low-density lipoprotein receptor and cyclo-oxygenase-2 gene expression in human colorectal cells and in colorectal adenocarcinoma biopsies
✍ Donald F. Lum; Kenneth R. McQuaid; Vicki L. Gilbertson; Millie Hughes-Fulford πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 French βš– 115 KB πŸ‘ 2 views

Many colorectal cancers have high levels of cyclo-oxygenase 2 (COX-2), an enzyme that metabolizes the essential fatty acids into prostaglandins. Since the low-density lipoprotein receptor (LDLr) is involved in the uptake of essential fatty acids, we studied the effect of LDL on growth and gene regul

Multiple levels of steroid hormone-depen
Multiple levels of steroid hormone-dependent control of osteocalcin during osteoblast differentiation: Glucocorticoid regulation of basal and vitamin D stimulated gene expression
✍ Victoria Shalhoub; Fauzia Aslam; Ellen Breen; AndrΓ© van Wijnen; Rita Bortell; Ga πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 306 KB πŸ‘ 1 views

We have examined the contribution of transcriptional mechanisms to the pleiotropic effects of glucocorticoids on basal and vitamin D stimulated expression of the developmentally regulated bone-specific osteocalcin (OC) gene. OC expression was systematically investigated at the level of protein, mRNA