Expression and prognostic value of plasminogen activator inhibitor type 1 in node-negative breast cancer
β Scribed by Bin Wang; Ning Wang; Chunyan Xue; Bin Jiang; Yajie Wang
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 406 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1610-1979
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We used an immunohistochemical assay with an antigenretrieval technique to study plasminogen activator inhibitor type-I (PAL I) expression in paraffin-embedded breast tissue samples at different stages of malignant transformation. We detected PAI-I in 15/20 invasive tumors. In several cases staining
## Abstract ## Background. Tumor cell biological factors, such as urokinase plasminogen activator (uPA) and its inhibitor plasminogen activator inhibitorβ1 (PAIβ1), cathepsin D, and cβmyc play a role in tumor invasion, metastasis, and proliferation. In this study, the prognostic importance of thes