A novel fusion of the MALT1 gene and the
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Eva M. Murga Penas; Holli Kawadler; Reiner Siebert; Matthias Frank; Hongtao Ye;
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Article
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2006
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John Wiley and Sons
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English
⚖ 557 KB
Rearrangements of the MALT1 gene by the t(11;18)(q21;q21) and t(14;18)(q32;q21) are the most frequent structural chromosomal abnormalities in MALT lymphomas. These translocations lead to fusions of BIRC3-MALT1 and IGH-MALT1 respectively, and activate the NF-kappaB pathway. Among 122 diffuse large B-