Expression and molecular dynamics studies on effect of amino acid substitutions at Arg344 in human cathepsin A on the protein local conformation

Effect of amino acid substitutions at th

Effect of amino acid substitutions at the subunit interface on the stability and aggregation properties of a dimeric protein: Role of Arg 178 and Arg 218 at the dimer interface of thymidylate synthase

✍ Variath Prasanna; B. Gopal; M.R.N. Murthy; Daniel V. Santi; Padmanabhan Balaram 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 273 KB 👁 2 views

The significance of two interface arginine residues on the structural integrity of an obligatory dimeric enzyme thymidylate synthase (TS) from Lactobacillus casei was investigated by thermal and chemical denaturation. While the R178F mutant showed apparent stability to thermal denaturation by its de