Expression and Methylation Pattern of p16 in Neuroblastoma Tumorigenesis
✍ Scribed by Safiye Aktas; Aydan Cavusoglu Celebiler; Zeynep Zadeoğluları; Gulden Diniz; Aydanur Kargı; Nur Olgun
- Book ID
- 107636340
- Publisher
- Springer Netherlands
- Year
- 2009
- Tongue
- English
- Weight
- 266 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1219-4956
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Alterations in the p16(INK4a) gene have been implicated in the pathogenesis of different human cancers and animal tumors. We postulated that alterations in the p16(INK4a) gene may also be involved in mouse colon tumorigenesis induced by the chemical carcinogen azoxymethane (AOM). In the present stud
Alterations of the p16 gene in neuroblastoma are very rare. Pronounced expression of p16 at both the transcript and protein levels, however, was observed in 7 of 19 (39%) neuroblastoma cell lines and 2 of 6 (33%) primary neuroblastoma samples. As p16 expression is tightly controlled in a feedback lo
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