✦ LIBER ✦

Expression and mapping of lubricin in canine flexor tendon

✍ Scribed by Yulong Sun; Evelyn J. Berger; Chunfeng Zhao; Gregory D. Jay; Kai-Nan An; Peter C. Amadio

Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 484 KB
Volume: 24
Category: Article
ISSN: 0736-0266
DOI: 10.1002/jor.20239

No coin nor oath required. For personal study only.

✦ Synopsis

Matrix composition and the biomechanical environment are intimately interdependent in most connective tissues. Lubricin has many distinct biological functions, including lubrication, antiadhesion, and cytoprotection in cartilage, tendons, and other tissues. This study investigated the distribution of lubricin in the canine flexor digitorum profundus (FDP) tendon by immunohistochemistry. Lubricin was found both on the tendon surface and at the interface of collagen fiber bundles within the tendon, where the cells are subjected to shear force in addition to tension and compression. The expression of lubricin in regions of the canine flexor tendon that differ in mechanical or nutritional environment was also investigated using RT-PCR. Six N-terminal splicing variants were identified from six distinct anatomical regions of flexor tendon. The variants with larger sizes were noted in regions subjected to significant shear and compressive forces. Lubricin is ubiquitous in the FDP tendon, with variations in distribution and splicing that appear to correspond to discrete anatomic locations that differ by mechanical or nutritional environment.

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