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Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells

✍ Scribed by Fan, Fan; Wey, Jane S; McCarty, Marya F; Belcheva, Anna; Liu, Wenbiao; Bauer, Todd W; Somcio, Ray J; Wu, Yan; Hooper, Andrea; Hicklin, Daniel J


Book ID
110069308
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
233 KB
Volume
24
Category
Article
ISSN
0950-9232

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## Abstract The human vascular endothelial growth factor receptor‐1 (VEGFR‐1, or Flt‐1) is widely expressed in normal and pathologic tissue and contributes to the pathogenesis of both neoplastic and inflammatory diseases. In human cancer, VEGFR‐1 mediated signaling is responsible for both direct tu