## Abstract Photoreceptors in the vertebrate retina are electrically coupled with one another. Such coupling plays important roles in visual information processing. Physiological properties of rodβrod and rodβcone coupling have been best studied in the salamander retina, yet the cellular and molecu
Expression and function of the neuronal gap junction protein connexin 36 in developing mammalian retina
β Scribed by Kristi A. Hansen; Christine L. Torborg; Justin Elstrott; Marla B. Feller
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 599 KB
- Volume
- 493
- Category
- Article
- ISSN
- 0021-9967
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Retinal neurons of virtually every type are coupled by gap-junctional channels whose pharmacological and gating properties have been studied extensively. We have begun to identify the molecular composition and functional properties of the connexins that form these 'electrical synapses,' and have clo
In rat brain, expression of the gap junction protein connexin30 increased during the first 3 weeks after birth and reached its maximum after 4 weeks, as shown by analysis with specific connexin30 antibodies. This contrasts with the prenatal onset of connexin43 expression. On cryosections of rat brai
Astroglial cells contribute to neuronal maintenance and function in the normal and diseased brain. Gap junctions formed predominantly by connexin43 (cx43) provide important pathways to coordinate astroglial responses. We have previously shown that fibroblast growth factor (FGF)-2, which occurs ubiqu
The connexins are a family of proteins that form the intercellular membrane channels of gap junctions. Genes encoding 13 different rodent connexins have been cloned and characterized to date. Connexins vary both in their distribution among adult cell types and in the properties of the channels that