Expression and DNA methylation patterns of Tslc1 and Dal-1 genes in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats
โ Scribed by Toshifumi Tsujiuchi; Eriko Sugata; Tomomi Masaoka; Mariko Onishi; Hiromasa Fujii; Kyoko Shimizu; Kanya Honoki
- Book ID
- 108583894
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 215 KB
- Volume
- 98
- Category
- Article
- ISSN
- 1347-9032
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The present study was conducted to assess whether Fhit gene alterations are a feature of hepatocellular carcinomas (HCCs) induced by N-nitrosodiethylamine (DEN) in male Fischer 344 rats. Animals, 6 wk old, received a single intraperitoneal injection of DEN at a dose of 10 mg/kg body weight, followed
## Abstract Investigating aberrant DNA methylation in the cancer genome may identify genes that play an important role in tumor progression. In this study, we combined differential methylation hybridization and a CpG microarray platform to characterize methylation profiles and identify novel candid
## Abstract To elucidate whether the M6p/Igf2 receptor (M6p/Igf2r) gene might be involved in exogenous and endogenous liver carcinogenesis, we investigated its alteration in hepatocellular carcinomas (HCCs) induced by __N__โnitrosodiethylamine (DEN) and by a cholineโdeficient Lโamino acidโdefined (