Expression and cytoplasmic localisation of deoxyuridine triphosphate pyrophosphatase encoded by a human endogenous retrovirus

The NP9 protein encoded by the human end

The NP9 protein encoded by the human endogenous retrovirus HERV-K(HML-2) negatively regulates gene activation of the Epstein-Barr virus nuclear antigen 2 (EBNA2)

✍ Henrik Gross; Stephanie Barth; Thorsten Pfuhl; Vivienne Willnecker; Andreas Spur 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 597 KB

Epstein-Barr virus (EBV) is a human tumour virus that efficiently growth-transforms primary human B-lymphocytes in vitro. The viral nuclear antigen 2 (EBNA2) is essential for immortalisation of B-cells and stimulates viral and cellular gene expression through interaction with DNA-bound transcription