Acquired imatinib resistance in chronic myelogenous leukemia (CML) can be the consequence of mutations in the kinase domain of BCR-ABL or increased protein levels. However, as in other malignancies, acquired resistance to cytostatic drugs is a common reason for treatment failure or disease progressi
✦ LIBER ✦
Expression analysis of PCNA gene in chronic myelogenous leukemia—Combined application of siRNA silencing and expression arrays
✍ Scribed by Michaela Merkerova; Hana Bruchova; Radim Brdicka
- Book ID
- 104040291
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 554 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0145-2126
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## Abstract Chromosomal aberrations observed in addition to the Philadelphia chromosome in chronic myelogenous leukemia (CML) are likely to be involved in disease progression to the blast crisis. We describe here a t(1;14)(q25;q32) as an additional chromosomal aberration in a patient with CML in bi
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