Exposure to time varying magnetic fields associated with magnetic resonance imaging reduces fentanyl-induced analgesia in mice
✍ Scribed by G. Campbell Teskey; Klaus-Peter Ossenkopp; Frank S. Prato; Martin Kavaliers
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 544 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0197-8462
No coin nor oath required. For personal study only.
✦ Synopsis
The effects of exposure to clinical magnetic resonance imaging (MRI) on analgesia induced by the mu opiate agonist, fentanyl, was examined in mice. During the dark period, adult male mice were exposed for 23.2 min to the time-varying (0.6 T/sec) magnetic field (TVMF) component of the MRI procedure. Following this exposure, the analgesic potency of fentanyl citrate (0.1 mg/kg) was determined at 5, 10, 15, and 30 min post-injection, using a thermal test stimulus (hot-plate 50°C). Exposure to the magnetic-field gradients attenuated the fentanyl-induced analgesia in a manner comparable to that previously observed with morphine. These results indicate that the time-varying magnetic fields associated with MRI have significant inhibitory effects on the analgesic effects of specific mu-opiate-directed ligands.