Exposure to ozone inhibits isolation-induced aggressive behavior of adult CD-1 male mice

✍ Scribed by S. Petruzzi; M. Fiore; G. Dell'Omo; Dr. E. Alleva

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 642 KB
• Volume: 21
• Category: Article
• ISSN: 0096-140X
• DOI: 10.1002/1098-2337(1995)21:5<387::aid-ab2480210508>3.0.co;2-0

✦ Synopsis

Continuous exposure to ozone (O,, 1.2 ppm) in adult CD-1 male mice for 20 consecutive days markedly influenced a number of items of aggressive behavior induced by 59 days of individual housing. The behavior of mice was videotaped on days 1,3, and 5 of five consecutive daily encounters (10 min each; isolation days 5557, and 59). Ozone exposure caused an abatement of aggressive behavior and enhanced fear-associated displays shown by a significant decrease in the frequency of attacking and digging and an increase in freezing. Moreover, 0, induced a decrease of time spent in attacking and exploration/activity. Nonexposed animals exhibited a day-dependent increase in self-grooming frequency which was not observed in 0, mice; by contrast, freezing was higher in 0, mice on day 5 of the test. Data suggest that 0, exposure produces a remarkable reduction of mouse aggression, indirectly confirming previous findings on physical and neurobehavioral effects of 0,. o 1995 Wiiey-Liss, Inc.