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Exposure of rat hippocampal neurons to amyloid β peptide (25–35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3β

✍ Scribed by Akihiko Takashima; Kaori Noguchi; Gilles Michel; Marc Mercken; Minako Hoshi; Koichi Ishiguro; Kazutomo Imahori


Book ID
116125302
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
313 KB
Volume
203
Category
Article
ISSN
0304-3940

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## Abstract Excitotoxicity and cell death induced by glutamate are involved in many neurodegenerative disorders. We have previously demonstrated that excitotoxicity induced by millimolar concentrations of glutamate in hippocampal slices involves apoptotic features and glutamate‐induced glutamate re