𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Exposure of cells to an acidic environment reverses the inhibiton by methylamine of the mitogenic response to epidermal growth factor

✍ Scribed by A.Christie King; Pedro Cuatrecasas


Book ID
115755731
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
371 KB
Volume
106
Category
Article
ISSN
0006-291X

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Modulation of the mitogenic response of
✍ Joseph G. Zendegui; Wendelyn H. Inman; Graham Carpenter πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 English βš– 818 KB

The stimulation of DNA synthesis by epidermal growth factor (EGF) has been studied for a cell line having properties useful for investigating the mechanism of action of EGF in epithelial cell populations. These studies employ a mouse keratinocyte cell line (MK), isolated by Weissman and Aaronson (1

Decreased mitogenic response to epiderma
✍ David L. Crowe; Kenneth J. Tsang πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 163 KB πŸ‘ 1 views

## Abstract Growth factor receptors of the tyrosine kinase family regulate proliferation of a variety of cell types. In some human cancers, the epidermal growth factor receptor (EGFR) and its ligands often are overexpressed, leading to both constitutive and autocrine activation. Intracellular signa

Mevalonate dependency of the early cell
✍ Marcela B. Ortiz; Mercedes Goin; Maria B. Gomez de Alzaga; Swen Hammarstrom; Lui πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 778 KB

Lovastatin (LOV), a hydroxy-methylglutaryl-coenzyme A (HMGCoA) reductase competitive inhibitor, blocks epidermal growth factor (EGF)or prostaglandin F , , (PGF,,)-induced mitogenesis in confluent resting Swiss 3T3 cells. This inhibition occurs even in the presence of insulin, which potentiates the a

Comparison of the ability of basic and a
✍ D. Gospodarowicz; J. PlouΓ«t; B. Malerstein πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 910 KB

## Abstract The bioactivity of both bFGF and aFGF in the BALB/MK‐1 cell line has been compared to that of EGF. Our results indicate that, for that cell type, aFGF was far more potent than bFGF in inducing cell proliferation. In the presence of heparin, aFGF was as potent as EGF. In addition, excess