## Abstract Physiologically based pharmacokinetic (PBPK) models are sophisticated dosimetry models that offer great flexibility in modeling exposure scenarios for which there are limited data. This is particularly of relevance to assessing human exposure to environmental toxicants, which often requ
โฆ LIBER โฆ
Exposure-integrated physiologically based pharmacokinetic models for risk assessment of environmental carcinogens
โ Scribed by Kenneth T. Bogen; Thomas E. McKone; David W. Layton
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 54 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0300-483X
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## Abstract In chemical safety assessment, information on adverse effects after chronic exposure to low levels of hazardous compounds is essential for estimating human risks. Results from __in vitro__ studies are often not directly applicable to the __in vivo__ situation, and __in vivo__ animal stu