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Exploring the interaction of microcystin-LR with proteins and DNA

✍ Scribed by L. Vela; E. Sevilla; C. Gonzalez; M.T. Bes; M.F. Fillat; M.L. Peleato

Book ID
116919885
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
591 KB
Volume
22
Category
Article
ISSN
0887-2333

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Association of microcystin-LR and its bi
Association of microcystin-LR and its biotransformation product with a hepatic-cytosolic protein
✍ Robinson, Nancy A. ;Matson, Charles F. ;Pace, Judith G. πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 967 KB

Microcystin-LR (MCYST-LR), a cyclic peptide hepatotoxin, associates with high-molecularweight, liver cytosolic components. Repetitive cycles of heat denaturation and pronase digestion released 80 ? 6% of the bound radiolabel from these components, parent toxin (22% ), and two biotransformation produ