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Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor

โœ Scribed by Samuel Hintermann; Konstanze Hurth; Joachim Nozulak; Marina Tintelnot-Blomley; Reiner Aichholz; Joachim Blanz; Klemens Kaupmann; Johannes Mosbacher


Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
493 KB
Volume
21
Category
Article
ISSN
0960-894X

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Trishomocubanes, a new class of selectiv
โœ Michael Kassiou; Vu H. Nguyen; Robert Knott; MacDonald J. Christie; Trevor W. Ha ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 279 KB

The synthesis, receptor binding, and preliminary structural characterisation of trishomocubanes of types pentacyclo [5.4.0.02'6.03'lยฐ.05'9]undecylamines and 4-azahexacyclo[5.4.1.0E'6.03'lยฐ.05'9.08'll]dodecanes are described. These ligands demonstrated high selectivity and affinity for the sigma bind