Exploration of a proposed biomimetic syn
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Yi Li; Gerald Pattenden
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Article
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2011
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Elsevier Science
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French
β 364 KB
A concise synthesis of the macrocyclic vinylbutenolide 19 is described, based on a facile RCM reaction of the substrates 16/18. Treatment of 19 with TFA containing water led to the 5,6,7-tricyclic compound 27, in a single step, in >90% yield, rather than to the alternative ring system 23 found in pl