Exploration of the pathogenesis of haemophilic joint arthropathy: understanding implications for optimal clinical management

The molecular pathogenesis of acute prom

The molecular pathogenesis of acute promyelocytic leukaemia: implications for the clinical management of the disease

✍ Anita R Mistry; Eva W Pedersen; Ellen Solomon; David Grimwade 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 815 KB

Acute promyelocytic leukaemia (APL) is characterised by chromosomal rearrangements of 17q21, leading to fusion of the gene encoding retinoic acid receptor alpha (RARalpha) to a number of alternative partner genes (X), the most frequent of which are PML (>95%), PLZF (0.8%) and NPM (0.5%). Over the la