Exploration of Gene-Environment Interactions, Maternal Effects and Parent of Origin Effects in the Etiology of Hypospadias
β Scribed by van der Zanden, Loes F.M.; Galesloot, Tessel E.; Feitz, Wout F.J.; Brouwers, Marijn M.; Shi, Min; Knoers, Nine V.A.M.; Franke, Barbara; Roeleveld, Nel; van Rooij, Iris A.L.M.
- Book ID
- 122089461
- Publisher
- Lippincott Williams and Wilkins
- Year
- 2012
- Tongue
- English
- Weight
- 575 KB
- Volume
- 188
- Category
- Article
- ISSN
- 0022-5347
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Many complex genetic effects, including epigenetic effects, may be expected to operate via mechanisms in the inter-uterine environment. A popular design for the investigation of such effects, including effects of parent-of-origin (imprinting), maternal genotype, and maternal-fetal genotype interacti
## Abstract Estimation and testing of genetic effects (genotype relative risks) are often performed conditionally on parental genotypes, using data from caseβparent trios. This strategy avoids having to estimate nuisance parameters such as parental mating type frequencies, and also avoids generatin