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Exploration and Suppression of Cardiac Amyloidosis Induced by Huntington's Disease-Causing Amyloid in the Drosophila Heart Model

✍ Scribed by Melkani, Girish C.; Bodmer, Rolf; Ocorr, Karen; Bernstein, Sanford I.


Book ID
122148681
Publisher
Biophysical Society
Year
2012
Tongue
English
Weight
81 KB
Volume
102
Category
Article
ISSN
0006-3495

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## Abstract Symptoms in the early stages of Huntington's disease (HD) are assumed to reflect basal ganglia circuit dysfunction secondary to degeneration of striatal projections to the external segment of the globus pallidus (GPe). The hypothesis that GPe lesion would ameliorate HD symptoms by β€œnorm