Experiments in the 5H-dibenzo[a,d]cycloheptene series. III. Synthesis of 10,11-substituted 5H-dibenzo[a,d]cycloheptene derivatives
β Scribed by G. J. B. Corts; W. Th. Nauta
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 371 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0165-0513
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The epoxides derived from 5H-dibenzo [a,d]cycloheptene and its 2-fluoro derivative were converted to trans-fused hydrofurans 4a,b (55 and 44% overall yields) via a five-step sequence, i.e. (i) epoxide ring opening using propargylmagnesium bromide, (ii) mercury(II)-induced cyclisation and in situ bro
The epoxides derived from 5H-dibenzo [a,d]cycloheptene and its 2-fluoro derivative were converted into the trans-fused hydropyran-3-one compounds (4aR\*,13bS\*)-(12-fluoro-)4,4a,9,13b-tetrahydrodibenzo [3,4:6,7]cyclohepta[1,2-b]pyran-3(2H)-one and the corresponding 3-amino derivative via two separat