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Experimentalin vivoandin vitrotreatment with a new histone deacetylase inhibitor belinostat inhibits the growth of pancreatic cancer

โœ Scribed by Dmitriy I Dovzhanskiy, Stefanie M Arnold, Thilo Hackert, Ina Oehme, Olaf Witt, Klaus Felix, Nathalia Giese, Jens Werner


Book ID
119897294
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
509 KB
Volume
12
Category
Article
ISSN
1471-2407

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## Abstract Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. In th