Experimental variables in the effects of postsession injections of strychnine sulphate on a classically conditioned response

✍ Scribed by Charles F. Levinthal; James D. Papsdorf

• Publisher: Springer
• Year: 1970
• Tongue: English
• Weight: 339 KB
• Volume: 17
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00402096

✦ Synopsis

Postsession strychnine injections have been shown to retard acquisition rates of the classically conditioned nictitating membrane response (CCNMR) of rabbits trained at a CS-US interval of 1000 msec. The particular interval value employed in CCNIRR acquisition was found to be important in the magnitude of the postsession strychnine effect. Strychnine Ss trained at a CS-US interval ~ 1250 msee (nonoptimal) were significantly depressed in acquisition rates relative to saline controls, while strychnine Ss trained at a CS-US interval ----250 msec (optimal) were not. Interpretations are based upon the presumed effects of CNS excitants on memory consolidation and possible neurological correlates of the CS-US interval parameter.