Experimental vaccine activities of recombinant E1 and E2 glycoproteins and hypervariable region 1 peptides of hepatitis C virus in chimpanzees
β Scribed by M. Esumi; T. Rikihisa; S. Nishimura; J. Goto; K. Mizuno; Y.-H. Zhou; T. Shikata
- Publisher
- Springer Vienna
- Year
- 1999
- Tongue
- English
- Weight
- 121 KB
- Volume
- 144
- Category
- Article
- ISSN
- 1432-8798
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## Abstract The Nβterminal end of the hepatitis C virus (HCV) envelope glycoprotein E2 contains a stretch of 27 amino acids that exhibit increased variability. This hypervariable region 1 (HVRβ1), as it is normally referred to, is thought to contain epitopes that come under humoral immune attack. I
## Abstract A rare collection of serum samples from patients with hepatitis C virus (HCV) infection followed up from the onset of clinical symptoms was acquired. RNA corresponding to the hypervariable region 1 (HVR1) of E2 protein of HCV isolated from nine patients was reverseβtranscribed, amplifie
Acute and chronic Hepatitis C virus infections were investigated retrospectively in chimpanzees that had been infected from a single source. Anti-E1 and anti-E2 were detected in two of three chimpanzees with a chronic infection, but were first detected 1 to 2 years after inoculation. Sequence evolut