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Experimental study the effects of selective catechol-O-metyltransferase (COMT) inhibitors on learning and memory

✍ Scribed by KHROMOVA, I; VORONINA, T; KRAINCVA, V; MANNISTO, P

Book ID
123485432
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
139 KB
Volume
31
Category
Article
ISSN
1043-6618

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## Abstract Inhibition of the enzyme catechol __O__‐methyltransferase (COMT) is of significant interest in the therapy of __Parkinson__'s disease. Described herein are structural analogs of the potent bisubstrate inhibitor (βˆ’)‐1 (__IC__~50~=9β€…nM; __Tableβ€…1__) for COMT, with target modifications of