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Experimental study on vascularized bone allografts for reconstruction of massive bone defects

✍ Scribed by Mitsunori Shigetomi; Kazuteru Doi; Noriyuki Kuwata; Keiichi Muramatsu; Hisashi Yamamoto; Shinya Kawai

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
711 KB
Volume
15
Category
Article
ISSN
0738-1085

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✦ Synopsis

Abstract

To study the healing mechanism of vascularized bone allografts under short‐term as well as long‐term immunosuppression with cyclosporin A, experimental vascularized intercalary bone allograft transplantation was carried out between inbred rats using the tibiofibula graft model. Bone scintigram and radiographs were used as an indicator for early detection of rejection after transplantation and bone union. In vascularized bone allografts under long‐term immunosuppression with cyclosporin A, early bone union and continuous incorporation were similar to that observed in vascularized bone autograft transplantation. When administration of cyclosporin A was discontinued before completion of bone union, the graft was rejected and bone union was delayed. Apparent swelling on the operated limb associated with a decrease in bone scintigram uptake suggested the occurrence of rejection of the allograft. Vascularized bone allograft transplantation is useful for reconstruction of massive bone defects only if immunosuppressants are used and maintained at least until bone union is obtained. © 1994 Wiley‐Liss, Inc.

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