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Experimental studies of tumor radioimmunodetection using antibody mixtures against carcinoembryonic antigen (CEA) and colon-specific antigen-p (CSAp)

✍ Scribed by Shaik A. Gaffar; Keshab D. Pant; Dan Shochat; Sidney J. Bennett; David M. Goldenberg

Publisher: John Wiley and Sons
Year: 1981
Tongue: French
Weight: 478 KB
Volume: 27
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910270116

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✦ Synopsis

Abstract

Experiments with the GW‐39 human colonic carcinoma growing in hamsters showed that injection of radioactive antibody to a colorectal‐specific, tumor‐associated antigen, CSAp, results in better tumor radiolocalization than was seen previously with radioantibodies to carcinoembryonic antigen (CEA). However, a mixture of both radioactive antibodies resulted in potentiation of CEA‐tumor radioimmunodetection without affecting CSAp‐tumor radiolocalization. Hence, multi‐marker antibody mixtures may be the method of choice in cancer radioimmunodetection.

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