Experimental respiratory syncytial virus infection of four species of primates

✍ Scribed by Dr. Robert B. Belshe; Linda S. Richardson; William T. London; D. Lewis Sly; John H. Lorfeld; Ena Camargo; David A. Prevar; Robert M. Chanock

• Publisher: John Wiley and Sons
• Year: 1977
• Tongue: English
• Weight: 322 KB
• Volume: 1
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.1890010302

✦ Synopsis

Abstract

Four species of nonhuman primates were inoculated intranasally with 10^3.1^ to 10^3.7^ plaque forming units (pfu) of respiratory syncytial (RS) virus. Adult squirrel monkeys and newborn rhesus monkeys became infected and shed small quantities (peak titer 10^2.0^ pfu/ml of nasopharyngeal swab specimen) of virus, but illness did not develop. Infant cebus monkeys aged 2 months became infected, shed 10^2.3^ to 10^3.8^ pfu/ml of nasopharyngeal swab specimen, but did not become ill. Chimpanzees aged 15 to 18 months shed a large quantity of virus, up to 10^6.0^ pfu/ml of nasopharyngeal swab specimen and developed an upper respiratory illness. Chimpanzees are proposed as a possible animal model for future study of the immunopathology of RS virus desease and for in vivo evaluation of attendated live virus vaccine candidates.