Experimental research of effectiveness of siRNA-Her-2/neu on drug sensitivity of Her-2/neu-over-expressing lung adenocarcinoma cell line
โ Scribed by Shu-hua Ren; Jing-wei Wang; Ping Qu; Yi Liu; Wei Zhang; Lin Zhang
- Book ID
- 107466819
- Publisher
- Chinese Anti-Cancer Association
- Year
- 2006
- Tongue
- English
- Weight
- 254 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1000-9604
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Geldanamycin belongs to the family of benzoquinoid ansamycin tyrosine-kinase inhibitors. We have examined its effects on Her-2/neu kinase activity, protein expression level, and proliferation of Her-2+ malignant cells. In SK-BR-3 breast-cancer cells, short-time treatment with geldanamycin completely