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Experimental model for testing the efficiency of immunotoxins administered in vivo: evaluation of two ricin A-chain — multivalent antibody immunotoxins

✍ Scribed by Gabriele Moţa; Marinela Mărgineanu; Radu Marcheş; Mariana Nicolae; Alexandru Bancu; Ioan Moraru

Book ID
107906201
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
694 KB
Volume
20
Category
Article
ISSN
0165-2478

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✍ Guo-Liang Shen; Jia-Ling Li; Maria-Ana Ghetie; Victor Ghetie; Richard D. May; Ma 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 668 KB

Ricin A chain-containing immunotoxins (IT-As) specific for the human &ell antigen, CD22, were prepared from 4 monoclonal antibodies (MAbs) or their Fab' fragments: RFB4, HD6, UV22-I and UV22-2. The ITS were tested for their ability to kill cells from the Burkitt lymphoma line, Daudi, the pre-6cell l