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Experimental lead neuropathy: Inorganic lead inhibits proliferation but not diffrentiation of Schwann cells

✍ Scribed by Dr Gen Sobue; David Pleasure

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 768 KB
Volume: 17
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410170508

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✦ Synopsis

Schwann cells were prepared from the sciatic nerves of newborn rats and cultured in a monolayer. Addition of lead acetate at concentrations between 0.4 and 10.0 Kg/ml, levels comparable to those occurring in neural tissues and physiological fluids of lead-intoxicated rats, diminished both the baseline rate of proliferation of the Schwann cells and their response to the mitogens, axolemmal fragments, glial growth factor, and the adenosine 3': 5'-cyclic monophosphate (CAMP) analogues 8-bromo-CAMP and dibutyryl-CAMP. This demonstrates a direct toxic effect of inorganic lead on Schwann cells. Lead acetate in this concentration range did not, however, inhibit the CAMP analogue-induced appearance of the "myelin marker" lipid galactocerebroside on the surfaces of the cultured Schwann cells.

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