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Experimental haemophilic synovitis: rationale and development of a murine model of human factor VIII deficiency

โœ Scribed by L. A. Valentino; N. Hakobyan; T. Kazarian; K. J. Jabbar; A. A. Jabbar


Book ID
108769461
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
229 KB
Volume
10
Category
Article
ISSN
1351-8216

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Factor VIII (FVIII) is a multidomain protein that is deficient in hemophilia A, a clinically important bleeding disorder. Replacement therapy using recombinant human FVIII (rFVIII) is the main therapy. However, approximately 15-30% of patients develop inhibitory antibodies that neutralize rFVIII act