Experimental evaluation of stem bark of Stryphnodendron adstringens (Mart.) Coville for antiinflammatory activity

✍ Scribed by J. C. S. Lima; D. T. O. Martins; P. T. de Souza Jr.

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 92 KB
• Volume: 12
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199805)12:3<218::aid-ptr220>3.0.co;2-4

✦ Synopsis

The acetone soluble fraction from the crude extract of Stryphnodendron adstringens stem bark was evaluated in acute and chronic models of inflammation. It was found to cause significant inhibition of rat paw oedema induced by carrageenan and dextran; the exudate volume and migration of leukocyte number in the rat pleurisy test and also in the hind paw swelling in rats on Freund's adjuvant-induced arthritis. In addition, it significantly decreased the vascular permeability increase caused by intraperitoneal acetic acid in mice. These findings support the traditional use of S. adstringens bark extracts in the treatment of inflammatory conditions.