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Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of biozzi mice

✍ Scribed by Nicholas E. Preece; Sandra Amor; David Baker; David G. Gadian; Janet K. O'Neill; Jutta Urenjak

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 676 KB
Volume: 32
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910320603

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Bioui AB/H mouse, marked increases in the initially low levels of N‐trimethyl compounds in the spinal cord were observed during probable demyelinating episodes. There was also a pronounced and reproducible modulation of the levels of taurine and myo‐inositol during acute and again during chronic relapsing EAE. The ratio of N‐acetyl‐aspartate to creatine in the spinal cord of mice infected with the mutant M9 strain of SFV decreased to approximately 70% of that seen in normal mice.

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