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Experimental drug intoxication: treatment with charcoal haemoperfusion

✍ Scribed by B. Widdop; R. K. Medd; R. A. Braithwaite; A. J. Rees; R. Goulding

Book ID: 104736263
Publisher: Springer-Verlag
Year: 1975
Tongue: English
Weight: 561 KB
Volume: 34
Category: Article
ISSN: 0340-5761
DOI: 10.1007/bf00353336

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✦ Synopsis

Dogs were given large doses of barbiturates, glutethimide, ethanol, methaqualone, ethchlorvynol, meprobamate, chloral hydrate, paracetamol and aspirin. These were treated by haemoperfusion using a column packed with charcoal coated with an acrylic hydrogel. Clearances for most drugs were significantly higher than those reported for haemodialysis. Minimal clearances of common biochemical entities were observed and although leucocyte and platelet counts were diminished, no deleterious effects attributable to this were encountered. Careful histological examination of tissues derived from perfused dogs revealed no evidence of charcoal emboli.

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